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Centromere protein R Rabbit anti-Human, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Brand: Proteintech 10743-1-AP-20UL
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Description
ITGB3BP is a transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. ITGB3BP acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. It induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. ITGB3BP may also act as an inhibitor of cyclin A-associated kinase. ITGB3BP may be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.Specifications
| Centromere protein R | |
| Polyclonal | |
| Unconjugated | |
| ITGB3BP | |
| Beta 3 endonexin, CENP R, CENPR, Centromere protein R, HSU37139, ITGB3BP, NRIF3, TAP20 | |
| Rabbit | |
| Antigen Affinity Chromatography | |
| RUO | |
| 23421 | |
| -20°C | |
| Liquid |
| Immunocytochemistry, Western Blot, Immunohistochemistry (Paraffin), Immunofluorescence | |
| 0.4 mg/mL | |
| PBS with 50% glycerol and 0.1% sodium azide; pH 7.3 | |
| Q13352 | |
| ITGB3BP | |
| Centromere protein R Fusion Protein Ag1204 | |
| 20 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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