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ATP2C1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Brand: Proteintech 13310-1-AP-20UL
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Description
ATP2C1, also known as secretory pathway Ca2+/Mn2+-ATPase (SPCA) 1, belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium from the cytosol to the Golgi lumen. Defects in this gene cause Hailey-Hailey disease, an autosomal domit disorder characterized by persistent blisters and erosions of the skin. Unlike the related protein ATP2C2, ATP2C1 is ubiquitously expressed and displays a lower maximal turnover rate for overall Ca2+-ATPase reaction and a higher apparent affinity for cytosolic Ca2+ activation of phosphorylation. Recent evidence suggests that ATP2C1 is a key regulator of insulin-like growth factor receptor (IGF1R) processing in tumor progression in basal breast cancers.Specifications
| ATP2C1 | |
| Polyclonal | |
| Unconjugated | |
| ATP2C1 | |
| ATP dependent Ca(2+) pump PMR1, ATP2C1, ATP2C1A, ATPase 2C1, HHD, hSPCA1, KIAA1347, PMR1, PMR1L, SPCA1 | |
| Rabbit | |
| Antigen Affinity Chromatography | |
| RUO | |
| 170699, 235574, 27032 | |
| -20°C | |
| Liquid |
| Western Blot, Immunocytochemistry, Immunofluorescence, Immunoprecipitation | |
| 0.2 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
| P98194, Q64566, Q80XR2 | |
| Atp2c1 | |
| ATP2C1 Fusion Protein Ag4143 | |
| 20 μL | |
| Primary | |
| Rat, Human, Mouse | |
| Antibody | |
| IgG |
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