Ambion™ Ambion™ In Vivo Pre-Designed siRNA

Description

Ambion In Vivo Predesigned siRNAs are specifically designed for gene silencing applications in animal models. These siRNAs are chemically modified to enhance stability, reduce immunogenicity, and improve delivery efficiency, making them excellent for in vivo studies. Ambion In Vivo Predesigned siRNAs allow researchers to investigate gene function in a physiological context, helping provide valuable insights into gene regulation mechanisms and disease processes. Built using the Silencer Select algorithm, these predesigned siRNAs help ensure high specificity and efficiency.

Key features include:

• Enhanced stability—chemical modifications help ensure that Ambion In Vivo Predesigned siRNAs remain stable in the bloodstream and within tissues, helping provide sustained gene silencing effects
• Reduced immunogenicity—modifications minimize immune responses, helping ensure safe and effective use in animal models
• Efficient delivery—optimized for use with various delivery systems, including lipid nanoparticles, helping ensure efficient uptake by target cells
• High specificity—designed to precisely target specific mRNAs, resulting in potent and specific gene knockdown

In vivo-ready siRNA

Ambion In Vivo Predesigned siRNAs are processed to be ready for in vivo use. This includes HPLC purification, membrane dialysis to remove salts and solvents, and sterile filtration prior to drying down.